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Paper Information

Journal:   JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)   DECEMBER 2010 , Volume 7 , Number 4; Page(s) 840 To 845.
 
Paper: 

A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES

 
 
Author(s):  ARABANIAN A., MOHAMMADNEZHAD M., BALALAEI S.*
 
* PEPTIDE CHEMISTRY RESEARCH CENTER, K.N. TOOSI UNIVERSITY OF TECHNOLOGY, TEHRAN, IRAN
 
Abstract: 

highly efficient and practical synthesis of C -terminal amidated peptides has been developed. According to this approach, amidation of the C- terminus of peptides was carried out using NH4Cl, alkylammonium chloride (RNH3Cl) and semicarbazide hydrochloride in the presence of TBTU as a coupling reagent and a tertiary amine as the base at room temperature in good to high yields. Some opioid peptides such as enkephalin derivatives were synthesized according to this novel method.

 
Keyword(s): MET-ENKEPHALIN, LEU-ENKEPHALIN, SOLID PHASE PEPTIDE SYNTHESIS, AMIDATION, C-TERMINAL AMIDATED PEPTIDES
 
 
References: 
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Cite:
APA: Copy

ARABANIAN, A., & MOHAMMADNEZHAD, M., & BALALAEI, S. (2010). A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 7(4), 840-845. https://www.sid.ir/en/journal/ViewPaper.aspx?id=189365



Vancouver: Copy

ARABANIAN A., MOHAMMADNEZHAD M., BALALAEI S.. A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS). 2010 [cited 2021April16];7(4):840-845. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=189365



IEEE: Copy

ARABANIAN, A., MOHAMMADNEZHAD, M., BALALAEI, S., 2010. A NOVEL AND EFFICIENT APPROACH FOR THE AMIDATION OF C-TERMINAL PEPTIDES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), [online] 7(4), pp.840-845. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=189365>.



 
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