Paper Information

Journal:   JOURNAL OF IRANIAN ANATOMICAL SCIENCES   SUMMER 2010 , Volume 8 , Number 31; Page(s) 85 To 94.
 
Paper: 

STUDY OF THE EFFECTS OF HEXAMETHYLENTETRAMINE ON DECREASE OF DEFECTS OF THE LUNG TISSUE IN THE RAT EXPOSED TO SULFUR MUSTARD

 
 
Author(s):  KAKA GH.R., SADRAEI S.H.*, MIRSHAFIEI GH.A., SABERI MAHDI, JAFARI MAHVASH
 
* ANATOMY DEPARTMENT, BAQIYATALLAH MEDICAL SCIENCES UNIVERSITY, TEHRAN
 
Abstract: 
Purpose: The aim of this study was to evaluate the effects of HMT on protection of lung tissue exposed to HD in the rat.
Materials and Methods: In this study twenty Albino Wister adult male rats weighting 200
±20 gram were used. Rats divided randomly into 4 groups (each group has 5 rats) as below: Normal saline group (NS), HMT group, HD group (0.25% HD) and HD+HMT group. Normal saline and HD solution were injected by intra tracheal catather. Animals in HMT and HD+HMT groups received HMT by intra peritoneal injection for 14 days daily. All rats were killed after 14 days, a part of lung tissue were removed, fixed and processed for histological evaluation by H&E staining and and apoptotic cell death study by TUNEL kit. In addition, biochemical study (catalase enzyme) was measured in all groups.
Results: Histological examination and cell counting data revealed that there were no significant differences between Saline & HMT groups. Alveolar hemorrhage and inflammation, as well as, the number of apoptotic cells in the HD group was significantly increased when compared to HD+HMT group.
Conclusion: HMT have prophylactic & therapeutics effects in the lung tissue against HD.
 
Keyword(s): SULFUR MUSTARD, LUNG TISSUE, HEXAMETHYLENETETRAMINE
 
References: 
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