Paper Information

Journal:   JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)   SUMMER 2010 , Volume 4 , Number 14; Page(s) 61 To 67.
 
Paper:  SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF TRIAMTERENE AND HYDROCHLOROTHIAZIDE IN TRIAMTERENE-H TABLETS USING CONTINUOUS WAVELET TRANSFORMATION
 
Author(s):  SOHRABI M.R.*, MOHAMMADPOUR KH.M., JOURABCHI A.
 
* DEPARTMENT OF CHEMISTRY, NORTH TEHRAN BRANCH, AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

A spectrophotometric method for simultaneous analysis of triamterene and hydrochlorothiazide is proposed by application of continuous wavelet transform on the spectral data without time-consuming extraction step.
Different wavelets families were tested and Coiflets wavelet family (coif1) and Reverse birothogonal wavelets family (rbio 2.8) were selected and applied under the optimal conditions for simultaneous analysis.
The validation of the developed methods was confirmed by analyzing various synthetic mixtures of the investigated drugs.
Triamterene and hydrochlorothiazide could be determined simultaneously in the range of 0.75-5.0
mg ml-1 and 1.0– 6.0 mg. ml-1 respectively and LOD for triamterene and hydrochlorothiazide was less than 1.07 mg. ml-1 and 0.89 mg. ml-1 respectively.
The experimental results obtained from the continuous wavelet transform approach were statistically compared with those obtained by derivative spectrophotometry and successful results were reported.

 
Keyword(s): CONTINUOUS WAVELET TRANSFORM, SIMULTANEOUS DETERMINATION, TRIAMTERENE, HYDROCHLOROTHIAZIDE
 
References: 
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