Paper Information

Journal:   IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)   DECEMBER 2011 , Volume 13 , Number 4; Page(s) 293 To 298.
 
Paper: 

A CASE OF MANTLE CELL LYMPHOMA WITH MULTIPLE LYMPHOMATOUS POLYPOSIS (CASE REPORT ARTICLE)

 
 
Author(s):  TABIB SEYED MASOUD*, RAVANBOD M.R., VALIZADEH TOUSI S.M., FARZANEH M.R.
 
* DEPARTMENT OF GASTROENTEROLOGY, SCHOOL OF MEDICINE, BUSHEHR UNIVERSITY OF MEDICAL SCIENCES, BUSHEHR, IRAN
 
Abstract: 

Multiple Lymphomatous Polyposis (MLP) is characterized by multiple polyps involving long segments of the GI tract. More than 75% of the cases are derived from pregerminal center B cells (mantle zone B cells) & less than 25% from germinal center B cells. Thus MLP is a heterogenous group that includes Mantle Cell Lymphoma (MCL) & Follicular Lymphoma (FL). Here we present a 75-year-old sailor who referred to us with abdominal pain, bloody diarrhea, iron deficiency anemia & lymphadenopathy in inguinal & femoral regions. The presence of intestinal polyposis in colonoscopic & endoscopic evaluations & the pathologic & immunohistochemical findings on tissue specimens that showed B cell lymphoma with moderate proliferative activity (50%) & nodular proliferation of small lymphocytes; accompanied with positivity for CD5, CD20, CD43 & negativity for CD3, CD10, CD23 revealed that these findings are consequent to MCL with accompanied MLP.

 
Keyword(s): MANTLE CELL LYMPHOMA, MULTIPLE LYMPHOMATOUS POLYPOSIS, NONE HODGKIN’S LYMPHOMA, POLYPOSIS
 
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