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Journal:   IRANIAN JOURNAL OF DIABETES AND OBESITY   APRIL 2010 , Volume 2 , Number 2; Page(s) 1 To 6.
 
Paper: 

Fasting Hyperglycemia And Insulin Resistance In Colorectal Adenomatous Polyps
 
 
Author(s):  Rezvanfar Mohammad Reza*, Ghahramani Ramin, Rafiei Mohammad, Mokhtari Mohammad Rasoul, Ghanbarpour Sanam
 
* DEPARTMENT OF INTERNAL MEDICINE, ARAK UNIVERSITY OF MEDICAL SCIENCES ARAK, IRAN
 
Abstract: 
OBJECTIVES: To investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps.MATERIALS AND METHODS: In this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (IGF-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with Adenomatous polyps). We also estimated homeostasis model assessment insulin resistance index (HOMA-IR) in two groups. Statistical analyses were performed using the Student T-test and Chi-square test. For all tests a P value£0.05 was considered to be statistically significant.RESULTS: The mean of waist circumference (P<0.01), waist to hip ratio (P<0.01), fasting serum glucose (P<0.05), total cholesterol (P<0.05), and LDL (P<0.05) were significantly higher in patients with adenomatous polyps. The mean of HDL was significantly lower in patients with adenomatous polyps (P<0.01). There was no relation between fasting serum insulin, IGF-1 and glucose tolerance test with adenomatous polyps. Hence HOMA-IR was higher in patients with adenomatous polyps (2.9±2.6 vs. 2.82±2.1), this difference was not significant statistically.CONCLUSION: Fasting hyperglycemia could be a risk factor to adenomatous polyps’ development. Although this study did not show any relation between insulin resistance index and adenomatous polyps, further studies are needed for more evaluation.
 
Keyword(s): HYPERGLYCEMIA, INSULIN RESISTANCE, COLORECTAL POLYPS
 
 
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APA: Copy

REZVANFAR, M., & GHAHRAMANI, R., & MOKHTARI, M., & GHANBARPOUR, S., & RAFIEI, M. (2010). FASTING HYPERGLYCEMIA AND INSULIN RESISTANCE IN COLORECTAL ADENOMATOUS POLYPS. IRANIAN JOURNAL OF DIABETES AND OBESITY, 2(2), 1-6. https://www.sid.ir/en/journal/ViewPaper.aspx?id=188974



Vancouver: Copy

REZVANFAR MOHAMMAD REZA, GHAHRAMANI RAMIN, MOKHTARI MOHAMMAD RASOUL, GHANBARPOUR SANAM, RAFIEI MOHAMMAD. FASTING HYPERGLYCEMIA AND INSULIN RESISTANCE IN COLORECTAL ADENOMATOUS POLYPS. IRANIAN JOURNAL OF DIABETES AND OBESITY. 2010 [cited 2022August08];2(2):1-6. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=188974



IEEE: Copy

REZVANFAR, M., GHAHRAMANI, R., MOKHTARI, M., GHANBARPOUR, S., RAFIEI, M., 2010. FASTING HYPERGLYCEMIA AND INSULIN RESISTANCE IN COLORECTAL ADENOMATOUS POLYPS. IRANIAN JOURNAL OF DIABETES AND OBESITY, [online] 2(2), pp.1-6. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=188974.
 
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