Paper Information

Journal:   IRANIAN JOURNAL OF DIABETES AND OBESITY   APRIL 2010 , Volume 2 , Number 2; Page(s) 1 To 6.
 
Paper: 

FASTING HYPERGLYCEMIA AND INSULIN RESISTANCE IN COLORECTAL ADENOMATOUS POLYPS

 
 
Author(s):  REZVANFAR MOHAMMAD REZA*, GHAHRAMANI RAMIN, RAFIEI MOHAMMAD, MOKHTARI MOHAMMAD RASOUL, GHANBARPOUR SANAM
 
* DEPARTMENT OF INTERNAL MEDICINE, ARAK UNIVERSITY OF MEDICAL SCIENCES ARAK, IRAN
 
Abstract: 

OBJECTIVES: To investigate fasting glucose, glucose tolerance, insulin resistance and insulin–like growth factor 1 in patients with or without colorectal polyps.
MATERIALS AND METHODS: In this cross-sectional study, we evaluated fasting glucose, insulin, insulin–like growth factor 1 (IGF-1), lipid profile and glucose tolerance test in 103 patients undergoing colonoscopy (52 normal and 53 with Adenomatous polyps). We also estimated homeostasis model assessment insulin resistance index (HOMA-IR) in two groups. Statistical analyses were performed using the Student T-test and Chi-square test. For all tests a P value
£0.05 was considered to be statistically significant.
RESULTS: The mean of waist circumference (P<0.01), waist to hip ratio (P<0.01), fasting serum glucose (P<0.05), total cholesterol (P<0.05), and LDL (P<0.05) were significantly higher in patients with adenomatous polyps. The mean of HDL was significantly lower in patients with adenomatous polyps (P<0.01). There was no relation between fasting serum insulin, IGF-1 and glucose tolerance test with adenomatous polyps. Hence HOMA-IR was higher in patients with adenomatous polyps (2.9
±2.6 vs. 2.82±2.1), this difference was not significant statistically.
CONCLUSION: Fasting hyperglycemia could be a risk factor to adenomatous polyps’ development. Although this study did not show any relation between insulin resistance index and adenomatous polyps, further studies are needed for more evaluation.

 
Keyword(s): HYPERGLYCEMIA, INSULIN RESISTANCE, COLORECTAL POLYPS
 
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