Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   WINTER 2011 , Volume 12 , Number SUPPLEMENT 1 (THE 1ST INTERNATIONAL STUDENT CONGRESS ON CELL AND MOLECULAR MEDICINE); Page(s) 107 To 107.
 
Paper: 

STEM CELL AND REGENERATIVE MEDICINE: P-149: NASAL SEPTUM DERIVED PROGENITORS: A NEW CELL SOURCE FOR REGENERATIVE MEDICINE

 
 
Author(s):  SHAFIEI A.*, KABIRI M., SOLEYMANI M., MASOUDI M.
 
* STEM CELL BIOLOGY DEPARTMENT, STEM CELL TECHNOLOGY RESEARCH CENTER, TEHRAN, IRAN
 
Abstract: 
Objective: Adult stem cells have attracted attention for clinical purposes. In this study we expected to isolate and comprehensively distinguish a subpopulation of multipotent cells within human nasal septal tissue, and performed a comparative study with other adult stem cells: Adipose Tissue-Mesenchymal Stem Cells Bone Marrow-Mesenchymal Stem Cells, and Unrestricted Somatic Stem Cells.
Materials and Methods: The nasal septum derived progenitors was characterized using flowcytometery, immunofluorescence, and real-time PCR.
Results: Nasal septal derived progenitors (NSPs) expressed pluripotency and mesoectodermal progenitors markers, CD106, CD166, CD90, CD105, HLA-ABC, and did not express hematopoetic markers: CD34, CD45 while particularly presented Prominin-1.
NSPs showed higher clonogenic potential and longer life-span than other stem cells. NSPs differentiated into mesodermic and ectodermic lineages including osteocytes, chondrocytes, and neuron, maintaining their plasticity in differentiation pathways is another interesting feature of NSDPs.
Conclusion: NSPs could be considered as an alternative cell source, which can bring them to the forefront of therapeutic purposes.
 
Keyword(s): CARTILAGE, DIFFERENTIATION, LONG TERM CULTURE, NASAL SEPTUM
 
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