Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   WINTER 2011 , Volume 12 , Number SUPPLEMENT 1 (THE 1ST INTERNATIONAL STUDENT CONGRESS ON CELL AND MOLECULAR MEDICINE); Page(s) 91 To 91.
 
Paper: 

MOLECULAR PATHOLOGY: P-114: ROSIGLITAZONE AMELIORATES THE HISTOLOGICAL PARAMETERS OF THE DORSAL ROOT GANGLION AND THE FUNCTIONAL ASSESSMENT AFTER SCIATIC NERVE INJURY IN RAT

 
 
Author(s):  NOURAFSHAN A., SHARIAT KH.*, KARBALAEI DOUST S., OMIDI A.
 
* JAHROM ISLAMIC AZAD UNIVERSITY, JAHROM, IRAN
 
Abstract: 
Objective: The present study investigates the effects of rosiglitazone (a peroxisome proliferators-activated receptor gamma) on the histological parameters of the dorsal root ganglion and its recovery potential of injured sciatic nerve in rat.
Materials and Methods: Rats were divided into 4 groups including Control, sham-operated, sciatic nerve crushes (SNC) and SNC+rosiglitazone treatment (5mg/ kg body weight/day). Sciatic functional index (SFI) is used to evaluate functional recovery. The quantitative histological parameters were evaluated using stereological method.
Results: The results revealed the volume and surface of A- and B- cells reduced in the SNC when compared with sham- operated group. After treating SNC animals with rosiglitazone the volume of A- and B-cells increased~30% and ~48% and the surface of them increased ~45% and ~21% as well as in comparison with non-treated animals after SNC. The number of the A, B- and satellite cells reduced in the SNC in comparison with sham- operated group. The number of A-, B- and satellite cells increased ~38%, ~34% and ~29% in SNC+rosiglitazone in comparison with nontreated crushed animals. The sciatic functional index (SFI) was different between sham-operated and SNC groups after nerve injury.
Conclusion: SFI recovered in rosiglitazone-treated rats after SNC rats in comparison with non-treated animals.
The results have demonstrated that rosiglitazone has a neuroprotective effect on the DRG and enhance the functional recovery after SNC in the rats.
 
Keyword(s): ROSIGLITAZONE, SCIATIC NERVE CRUSH, DORSAL ROOT GANGLION, STEREOLOGY
 
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