Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   WINTER 2011 , Volume 12 , Number SUPPLEMENT 1 (THE 1ST INTERNATIONAL STUDENT CONGRESS ON CELL AND MOLECULAR MEDICINE); Page(s) 87 To 87.
 
Paper: 

MOLECULAR PATHOLOGY: P-105: LIPOLYTIC EFFECT OF SUBCUTANEOUS BOTULINUM TOXIN INJECTION IN RABBITS

 
 
Author(s):  BAGHERI M., MOEIN JAHROMI B.*, BAGHERI M-, BORHANI HAGHIGHI A., NOURAFSHAN A., VIJAI KUMAR P., RANJBAR OMRANI GH.H.
 
* STUDENT RESEARCH CENTRE, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 
Objective: Parasympathetic nervous system modulates adipose tissue as an endocrine gland. Botulinum toxin (BTX) may exert a lipolytic effect by interfering with acetylcholine transmission at the cholinergic parasympathetic nerve endings.
Materials and Methods: Fifteen male rabbits were divided into three equal groups: one control group (A) and two case groups (B and C). The abdomens of all rabbits were divided into a 3-by- 3-square grid. The control and two case groups received 9 subcutaneous injections of 0.9% normal saline, 1 U BTX (group B) and 2 U BTX (group C), respectively. Four weeks later the entire grid was excised from the abdominal area. Hematoxylineosin- stained tissue was used for stereological analysis to estimate cell surface and volume in 100 randomly selected cells.
Results: Gross thinning of subcutaneous fat, shattering and disappearance of fat globules were seen in both case groups. Fat cell volume was reduced by 65% in group B (p=0.009) and by 77% in group C (p=0.009) compared to the control animals. Fat cell surface also decreased by 51% in group B (p=0.009) and 63% in the group C rabbits (p=0.009) compared to the control animals.
Conclusion: Our pilot animal study revealed a dosedependent lipolytic effect of subcutaneous BTX injection.
 
Keyword(s): BOTULINUM TOXIN, ADIPOSE TISSUE, LIPOLYSIS
 
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