Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   WINTER 2011 , Volume 12 , Number SUPPLEMENT 1 (THE 1ST INTERNATIONAL STUDENT CONGRESS ON CELL AND MOLECULAR MEDICINE); Page(s) 71 To 71.
 
Paper: 

GENETICS IN MEDICINE: P-69: ASSOCIATION OF ANGIOTENSIN-CONVERTING ENZYME (ACE) GENE A/G POLYMORPHISM AND CORONARY HEART DISEASE

 
 
Author(s):  ZIAEI S.A., MIRFAKHRAEI R., ABD ALGHAFOURIAN H.*, BINA B., HARIRI R.
 
* SHAHID BEHESHTI MEDICAL UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Objective: Cardiovascular diseases comprise the most prevalent serious disorders in industrialized nations and are a rapidly growing problem in developing nations. Coronary heart disease is still a major cause of death and is responsible for 40% of all deaths each year. The Angiotensin-Converting Enzyme (ACE) is one of the most studied candidate genes related to hypertension and ventricular hypertrophy. The aim of this study is to investigate the association of Angiotensin-Converting Enzyme (ACE) gene A/G polymorphism with coronary heart disease.
Materials and Methods: This study is conducted in 212 Iranian patients of two groups: first group with established coronary heart disease and second control group. DNA was extracted from patients’ blood samples. Then the alleles of Angiotensin-Converting Enzyme (ACE) gene were detected using Polymerase Chain Reaction (PCR) and subsequent restriction digestion in all samples.
Results: Angiotensin-Converting Enzyme (ACE) gene A/G polymorphism was higher in group with coronary heart disease.77% of first group had the G allele polymorphism and only 25% of control group had the G allele.
Conclusion: Cardiovascular disease is now the most common cause of death worldwide. It has been shown that Angiotensin-Converting Enzyme (ACE) activity is associated with higher risk of hypertension and Diabetes Mellitus and hence, is a risk factor for coronary heart disease. In this study it is concluded that Angiotensin-Converting Enzyme (ACE) gene A/G polymorphism is associated with a higher risk of Coronary heart disease.

 
Keyword(s): ANGIOTENSIN, CONVERTING ENZYME (ACE), CORONARY HEART DISEASE
 
References: 
  • ندارد
 
  Yearly Visit 43
 
Latest on Blog
Enter SID Blog