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Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   2003 , Volume 11 , Number 2; Page(s) 74 To 78.
 
Paper: 

SYNTHESES AND ANTICONVULSANT ACTIVITY OF N4-SUBSTITUTED TRIAZOLYLTHIAZOLES

 
 
Author(s):  BINESH MARVASTI M., SHARIFZADEH M., JALILIAN A.R., SOLTANINEZHAD K., SHAFIEI A.*
 
* Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
 
Abstract: 

Due to the good anticonvulsant activity of various 1,2,4-triazoles, several new N4-substituted triazolylthiazoles were prepared by the general method for 1,2,4-triazole ring closure. Anticonvulsant activity of compounds was measured against pentylenetetrazole-induced seizures in mice by intraperitoneal injections of different doses of the test compounds. Pretreatment of animals with Flumazenil (10 mg/kg, i.p.) as a benzodiazepine receptors antagonist did not have any significant effect on anticonvulsant activity of the test compounds. These results demonstrate that the anticonvulsant activity of N4-substituted triazolylthiazole agents is not probably mediated by direct interaction with benzodiazepine receptor complex.

 
Keyword(s): 1, 2 ,4-TRIAZOLES, ANTICONVULSANT, THIAZOLES, FLUMAZENIL, PENTYLENETETRAZOLE
 
References: 
 
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