Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   2003 , Volume 11 , Number 2; Page(s) 69 To 73.
 
Paper: 

COMPARISON OF SUCRALFATE AND HYDROCORTISONE ENEMAS IN TREATMENT OF ACTIVE ULCERATIVE PROCTITIS; A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  JAVADI M.R., EBRAHIMI DARYANI N., GHOLAMI KH.A.*, MIRMOUMEN SH., FOROUTAN H., AMANLOU M., BAHRAMI H., HAGHPANAH BEHZAD, ASAD HASHTRUDI A.
 
* Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155-6451, Iran
 
Abstract: 

Sucralfate enema has been proposed and investigated in treatment of ulcerative proctitis, but its efficacy is still a matter of debate. Hydrocortisone enema is still an established drug in treatment of ulcerative proctitis. This study was designed to compare the effect of sucralfate enema with hydrocortisone enema. Patients with active sigmoidoscopic and histologic features of ulcerative proctitis were included. All patients had clinical manifestations of proctitis for at least four weeks prior to the study and had negative parasitic stool culture. The total of 25 patients entered the study. They were randomly divided in two groups; group I (n =11) and group II (n = 11) who received sucralfate and hydrocortisone enemas respectively for 4 weeks. Both groups had a significant improvement in clinical features, histologic activity and sigmoidoscopic evaluation in comparison with the baseline. Furthermore there was no significant difference between the two groups concerning mean changes of clinical, sigmoidoscopic, and histologic grading, after treatment. Considering the low cost and minimal adverse effects of sucralfate, and almost equal efficacy in comparison with hydrocortisone enema, its usage can be recommended.

 
Keyword(s): SUCRALFATE, HYDROCORTISONE, ULCERATIVE COLITIS, PROCTITIS, ENEMA
 
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