Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   2003 , Volume 11 , Number 2; Page(s) 38 To 46.
 
Paper: 

COMPARISON OF AUTOMATED CONTINUOUS FLOW METHOD WITH SHAKE- FLASK METHOD IN DETERMINING PARTITION COEFFICIENTS OF BIDENTATE HYDROXYPYRIDINONE LIGANDS

 
 
Author(s):  SAGHAEI L.A.*, HIDER R.C., MOSTAFAVI S.A.
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, FACULTY OF PHARMACY AND PHARMACEUTICAL SCIENCES, ISFAHAN UNIVERSITY
 
Abstract: 

The partition coefficients (Kpart, in octanol/water system) of a range of bidentate legends containing the 3-hydroxypyridin-4-one moiety were determined using shake flask and automated continuous flow methods (filter probe method)). The shake flask method was used for extremely hydrophilic or hydrophobic compounds with a Kpart, values greater than 100 and less than 0.01. For other legends which possess moderate lipophilicity (Kpart, values between 0.01-100) the filter probe method was used. Also the partition coefficient of four legends with moderate lipophilicity was determined by shake flask method in order to check comparability of these two methods. While the shake flask method was able to determine either extremely hydrophilic or hydrophobic compounds efficiently, the filter probe method was unable to measure such Kpart, values. Although, determination of the Kpart, values of all compounds is possible with the classical shake-flask method, the procedure is time consuming. In contrast, the filter probe method offers many advantages over the traditional shake flask method in terms of speed, efficiency of separation and degree of automation. The shake-flask method is the method of choice for determination of partition coefficients of extremely hydrophilic and hydrophobic legends.

 
Keyword(s): PARTITION COEFFICIENTS, 3-HYDROXYPYRIDIN-4-ONE, SHAKE FLASK METHOD, FILTER PROBE METHOD, BIDENTATE LIGAND
 
References: 
 
  pdf-File tarjomyar Yearly Visit 124
 
Latest on Blog
Enter SID Blog