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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   May 2004 , Volume 3 , Number Supplement 1; Page(s) 34 To 34.
 
Paper: 

DEPRENYL CHANGES THE EXPRESSION OF TRK-B AND P75 NTR RECEPTORS IN RAT AFTER SCIATIC NERVE AXOTOMY

 
 
Author(s):  HESHMATI MARJAN*, ALTARIHI T., MOULA SEYED JAVAD
 
* FACULTY OF MEDICINE, SHAHED UNIVERSITY, TEHRAN
 
Abstract: 

During development many of neurons die by the phenomenon named programmed cell death or apoptosis and this reaction is regulated by neurotrophin (BDNF, NGF, NT3 and NT4/5). These neurotrophins bind to two different classes of transmembrane receptor proteins, the Trks and P75 NTR. Axotomy can induce apoptosis after birth and deprenyl is a an inhibitor of monoamineoxidase type-B and seems to act as a neuroprotective factor and reduces apoptosis after sciatic nerve axotomy. The aim of this research was to study the effect of deprenyl (2.5 mg/kg, i.p.) following axotomy in newborn rat and to study the changes in expression of Trk-B and P75 NTR by RT-PCR. The segment of L4-L6 was studied after sciatic nerve axotomy. This study was conducted on 2 groups, control (normal saline injection) and experimental (deprenyl injection) and each group was classified into 3 subgroups on the basis of the time of injection and axotomy. In all of the 6 subgroups, 4 hours after injection, they were sacrificed and the segments L4-L6 of spinal cord processed by RT-PCR. The results showed that deprenyl increases expression of Trk-B, but decreases expression of P75 NTR as compared to control group.

 
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