| Abstract:
In the present study, the effects of intra-cerebral hippocampus (CA1) injections of apomorphine D1, D2-like receptors agonists on morphine-induced place preference in male Wistar rats have been investigated. Subcutaneous administration of different dose of morphine sulphate (1, 3, 6 and 9 mg/kg) produced a dose-dependent conditioned place preference (CPP). Intra-cerebral hippocampus (CA1) administration of apomorphine (0.25, 0.5 and 1 ?g/rat) 5 days before measuring CPP (using a 3-day schedule at the specific time) with an ineffective dose of morphine (1 and 3 mg/kg) decreased a significant CPP. In other words, apomorphine (0.25, 0.5, and 1 ?g/rat) injection into hippocampus decreased CPP in combination with morphine (1 and 3 mg/kg). Since apomorphine is D1, D2-like receptors agonist of dopamine and has sensitized both receptors, the study of which of these receptors causes the significant CPP reduction is going on.
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Cite:
APA: Copy
ROSTAMI, P., & NASEHI, M., & ZARINDAST, M., & REZAYOF, A. (2004). SENSITIVITY CHANGE OF DOPAMINE RECEPTORS IN HIPPOCAMPUS
(CA1) AND ITS EFFECT ON MORPHINE-INDUCED CONDITION PLACE PREFERENCE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 3(Supplement 1), 33-33. https://www.sid.ir/en/journal/ViewPaper.aspx?id=14425
Vancouver: Copy
ROSTAMI P., NASEHI M., ZARINDAST M.R., REZAYOF A.. SENSITIVITY CHANGE OF DOPAMINE RECEPTORS IN HIPPOCAMPUS
(CA1) AND ITS EFFECT ON MORPHINE-INDUCED CONDITION PLACE PREFERENCE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR). 2004 [cited 2021April18];3(Supplement 1):33-33. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=14425
IEEE: Copy
ROSTAMI, P., NASEHI, M., ZARINDAST, M., REZAYOF, A., 2004. SENSITIVITY CHANGE OF DOPAMINE RECEPTORS IN HIPPOCAMPUS
(CA1) AND ITS EFFECT ON MORPHINE-INDUCED CONDITION PLACE PREFERENCE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), [online] 3(Supplement 1), pp.33-33. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=14425>.
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