Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   May 2004 , Volume 3 , Number Supplement 1; Page(s) 22 To 22.
 
Paper: 

ROLE OF ADENOSINE RECEPTORS AND PROTEIN PHOSPHATASES IN THE REVERSAL OF PENTYLENETETRAZOL-INDUCED POTENTIATION PHENOMENON BY THETA PULSE STIMULATION IN THE CA1 REGION OF RAT HIPPOCAMPAL SLICES

 
 
Author(s):  OMRANI A.*, FATH ELAHI Y.
 
* DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARRES UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

The effect of theta pulse stimulation (TPS) on pentylenetetrazol (PTZ)-induced long-term potentiation of population spikes (PS) was studied in the hippocampal CA1 in vitro. A transient PTZ application produced a long-lasting enhancement of PS amplitude. A 3-min episode of TPS delivered at a higher intensity produced complete reversal of the PTZ potentiation when delivered during the last minutes of PTZ application. Prior application of high-intensity TPS also decreased the amount of PTZ potentiation, whereas it had no long-lasting effect on baseline synaptic responses. High-intensity TPS induced reversal was blocked by adenosine A1 receptor antagonist and, furthermore, was reduced by protein phosphatase 1 inhibitor. The results suggest that mechanism of PTZ-induced LTP reversal involves activation of adenosine receptors and protein phosphatases.

 
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