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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   Summer 2003 , Volume 2 , Number 3; Page(s) 167 To 171.
 
Paper: 

THE EFFECT OF ORAL ADMINISTRATION OF L-TYROSINE, FOLIC ACID AND PYRIDOXINE ON PERPHENAZINE INDUCED CATATONIA IN RAT

 
 
Author(s):  ARZI A.*, REZAEI MOHSEN
 
* DEPARTMENT OF PHARMACOLOGY, SCHOOL OF PHARMACY, AHVAZ UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

L-tyrosine, B6 and folic acid are involved in biosynthesis of DOPA and consequently dopamine. The aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in rats. Murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. A significant decrease in muscular rigidity was observed in groups that received L-tyrosine. However, groups which had received vitamin (s) only showed no significant decrease in muscular rigidity as compared with the control group. On the other hand, the group receiving folic acid plus L-tyrosine showed a lower degree of muscular rigidity in comparison with the other groups.
In conclusion, L-tyrosine has been found to be effective in improving perphenazine-induced muscular rigidity. Furthermore, when used in combination with folic acid, L-tyrosine could be found advantageous in the early stages of Parkinson’s disease.

 
Keyword(s): L-TYROSINE, FOLIC ACID, PYRIDOXINE, PARKINSON S DISEASE, RAT
 
References: 
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