Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   WINTER 2003 , Volume 2 , Number 1; Page(s) 47 To 50.
 
Paper: 

GELATIN MICROSPHERES FOR THE CONTROLLED RELEASE OF ALL-TRANS-RETINOIC ACID TOPICAL FORMULATION AND DRUG DELIVERY EVALUATION

 
 
Author(s):  DINARVAND R.*, RAHMANI ELHAM, FARBOD E.
 
* DEPARTMENT OF PHARMACEUTICS, FACULTY OF PHARMACY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 
A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150mm. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed Higuchi kinetics of release. However, drug release from the cream formulation followed zero order release profile.
 
Keyword(s): ALL-TRANS-RETINOIC ACID, TRETINOIN, MICROENCAPSULATION, GELATIN MICROSPHERES, COACERVATION, ZERO ORDER RELEASE, TOPICAL CREAM
 
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