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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   WINTER 2003 , Volume 2 , Number 1; Page(s) 11 To 15.
 
Paper: 

INTERACTION OF CISPLATIN WITH CELLULAR MACROMOLECULES: A FOURIER TRANSFORM INFRARED SPECTROSCOPY STUDY

 
 
Author(s):  HOSSEINI SHIRAZI F.*, WONG P.T.T., GOEL R.
 
* DEPT. OF TOXICOLOGY AND PHARMACOLOGY, SCHOOL OF PHARMACY, SHAHEED BEHESHTI UNIVERITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. Cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. The nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. We examined the interactions of platinum with human ovarian OV 2008 cancer cells by infrared spectroscopy, through the exposure of this cell line to cisplatin. These studies showed that there was an interaction between cisplatin and DNA and proteins. Nature of these interactions and their possible effects are discussed in this paper. In summary, it has caused denaturation of proteins and modification of the interchain packing of the DNA. Our results show that infrared spectroscopy is a potentially useful technique for monitoring the interaction of elements and drugs with cell components.

 
Keyword(s): CISPLATIN, FOURIER TRANSFORM, INFRARED SPECTROSCOPY, OVARIAN CARCINOMA, DNA, RNA, CELL MEMBRANE
 
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