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Paper Information

Journal:   INTERNATIONAL JOURNAL OF RADIATION RESEARCH   2003 , Volume 1 , Number 1; Page(s) 37 To 44.
 
Paper: 

PREPARATION, DISTRIBUTION, STABILITY AND TUMOR IMAGING PROPERTIES OF [62ZN] BLEOMYCIN COMPLEX IN NORMAL AND TUMOR-BEARING MICE

 
 
Author(s):  JALILIAN A.R.*, FATEH B., GHERGHEREHCHI M., KARIMIAN A., MATLLOOBI M., MORADKHANI S., KAMALI DEHGHAN M.
 
* Nuclear Research Center for Agriculture & Medicine, AEOI karaj, Iran
 
Abstract: 
Backgrounds: Bleomycin (BLM) has been labeled with radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [62Zn] zinc chloride for oncologic PET studies.

Materials and methods: The complex was obtained at the pH=2 in normal saline at 90 ° C in 60 min. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). Stability of complex was checked in vitro in mice and human plasma/urine.

Results: Preliminary in vivo studies performed to determine complex stability and distribution of [62Zn] BLM in normal and fibrosarcoma-bearing mice. [62Zn] BLM accumulated significantly in induced fibrosarcoma tumors in mice according to bio-distribution/imaging studies.

Conclusion: [62Zn] BLM can be used in PET oncology studies due to its suitable physico-chemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in higher animals
 
Keyword(s): PET, PHARMACOKINETIC, BIODISTRIBUTION, ZINC-62, BLEOMYCIN
 
References: 
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