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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   Fall 2002 , Volume 1 , Number 1; Page(s) 55 To 59.
 
Paper: 

TISSUE DISTRIBUTION OF 125I-HUMAN NONSPECIFIC POLYCLONAL IGG IN NORMAL AND INDUCED INFLAMMATION MICE

 
 
Author(s):  SHAHHOSSEINI S.*, BABAEI M.H., NAJAFI R.
 
* Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran
 
Abstract: 
Many different radiolabeled antibodies have been used for radioimmunotherapy and radioimmunoscintigraphy of human diseases in animal experiments. In order to study the in vivo tissue distribution of antibody, we labeled human nonspecific polyclonal IgG with Na125I using chloramine-T method. An animal model was developed by injecting turpentine in the posterior left thigh of Balb/c mice. Tissue distribution of 125I-IgG was assessed in normal and induced inflammation mice. Although labeled IgG accumulated in normal tissues such as liver, spleen and blood, its localization in inflammatory left thigh was significantly different from normal right thigh. Thus, by using the radiolabeling methods of IgG in order to increase the target-to-background ratio, antibody scintigraphy could be suggested as a powerful diagnostic tool for inflammation
 
Keyword(s): IMMUNOSCINTIGRAPHY; TURPENTINE; IMMUNOGLOBULIN (IG); PERCENT INJECTED DOSE PER GRAM TISSUE (% ID/G).
 
References: 
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