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Paper Information

Journal:   JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   Summer-Fall 2003 , Volume 2 , Number 3-4; Page(s) 137 To 142.
 
Paper: 

MENSTRUAL CYCLE STATUS IN PATIENTS WITH OVARIAN POLYCYSTIC SYNDROME UNDER TREATMENT WITH METFORMIN

 
 
Author(s):  TABATABAEI BAFGHI A.*, MOJIBIAN M.
 
* Dept. of Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd,
 
Abstract: 

Background: One of the causes of abnormal uterine bleeding (AUB) in women is polycystic ovarian syndrome (PCOS). Different treatments have been suggested for this syndrome. In this study, the menstrul cycle regulation was ecaluated in patients with PCOS who were under metformin therapy.
Materials and Methods: This clinical trial study was carried out on 120 women with PCOS in Bahman clinic in 1380-1381. The patients received 1500mg metformin daily for 6 months and their menstrual status was assessed monthly.
Results: After 2 months of treatment, 16 women (13.3%) had regular menses and 80 women (66.7%) had regular menstruation after 6 months of treatment. Age of women did not have any effect on the treatment, but BMI was effective. The mean of BMI in treated patients was higher than the untreated ones. The side effects of metformin were nausea (16.7% ), lack of appetite (16.7%) and diarrhea (13.3%).
Conclusion: It seems that administration of metformin regulates the menstral cycle in patients with PCOS.

 
Keyword(s): MENSTRUAL CYCLE, IRREGULAR BLEEDING, PCOS, METFORMIN
 
References: 
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