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Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   2005 , Volume 13 , Number 1; Page(s) 6 To 40.
 
Paper: 

MICRODOSE 14C UREA BREATH TEST FOR THE DIAGNOSIS OF HELICOBACTER PYLORI: A SURVEY IN IRANIAN POPULATION

 
 
Author(s):  DOWLATABADI BAZAZ R., KHALAJ A., BEYKI D., EFTEKHARI MEHRDAD, AL-SEYED HOSEIN M.H., KHOUSHAYAND M.R.
 
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Abstract: 
The carbon -14 urea breath test (UBT)is a non-invasive and simple method for the diagnosis of Helicobacter pylori infection. Attempts have been made to use lower doses of 14C-urea in the UBT in order to reduce the radiation risk of the test. The aim of this study was to assess the accuracy of a microdose (1 µCi [37 KBq]) 14C-UBT in Iranian population for validation of its diagnostic accuracy against gold standard methods. Eighty and two patients were subjected to upper gastrointestinal endoscopy as well as 14C-UBT in one week. Rapid urease test and histological examinations were used as gold standard. Breath samples were collected 10, 20 and 30 minute after ingestion of 1 µCi of 14C- urea solution and their activities were measured using a scintillation counter and expressed as counts per minute (cpm) and disintegration per minute (dpm). Good agreement was observed between the 14C-UBT and gold standard for samples which were collected 20 minutes after 14C-urea administration. The 14CUBT showed 100% sensitivity, 95% specificity, 95.45% positive predictive value, 100% negative predictive value and 97.50% accuracy. The results of this study showed good concordance between the 14C-UBT and invasive methods.
 
Keyword(s): HELICOBACTER PYLORI, UREA BREATH TEST, CARBON-14, MICRODOSE
 
References: 
 
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