Paper Information

Journal:   IRANIAN INTERNATIONAL JOURNAL OF SCIENCE   Fall 2000 , Volume 1 , Number 2; Page(s) 99 To 108.
 
Paper: 

EFFECT OF PECTIC ACID AND B-GLUCAN ON PROLACTIN SECRETION BY OVINE PITUITARY EXPLANTS

 
 
Author(s):  SEPEHRI H.*, ZORAGHI R., HAERI ROUHANI SEYED ALI
 
* University of Tehran, Iran
 
Abstract: 
Recent studies have indicated that several plant extracts reputed to be lactogenic are capable of inducing b-casein synthesis in mammary epithelial cells. This enhancement is mediated through a stimulation of prolactin release from lactotropes in anterior pituitary. Therefore it is admitted that these extracts are capable of stimulating prolactin secretion from hypophysis. A partial purification of these extracts, revealed that their active compounds are pectin in most cases and b-glucan in other cases. In this work, the effect of various concentrations of both pure pectic acid and b-glucan on prolactin secretion from ewe hypophysis fragments is investigated. It is shown that pectic acid in the 50-150 mg/ml range concentration and b-glucan in the 200-400 mg/ml range concentration are capable of stimulating prolactin secretion significantly (P<0.05, P<0.01), from hypophysis explants.
 
Keyword(s): PECTIC ACID, B-GLUCAN, PROLACTIN SECRETION, OVINE PITUITARY EXPLANTS
 
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