Paper Information

Journal:   ACTA MEDICA IRANICA   2002 , Volume 40 , Number 4; Page(s) 223 To 225.
 
Paper: 

LYMPH NODE REVEALING SOLUTION: A PROSPECTIVE STUDY ON 35 PATIENTS WITH COLORECTAL CARCINOMAS

 
 
Author(s):  SALEKI S.*, HAERI H.
 
* DEPARTMENT OF PATHOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 
Lymph node dissection is of prime importance for accurate staging of colorectal carcinomas. Since a great number of small lymph nodes are missed in the traditionalmethod, several fat clearing solutions have been introducedfor easier detection of smaller lymph nodes.In this study we evaluated the efficacy of a newfat clearing solution so-called Lymph Node Revealing Solution (LNRS) in colectomy specimens of patients with colorectalcarcinomafrom year 2000 till 2002, thirty five colectomyspecimens with less than 4 metastatic lymph nodes received in the pathology department of IKMC, were selected and re-evaluated using the LNRS. By using this solution 456 additional lymph nodes and 16 more metastatic lymph nodes were detected resulting in upstaging of 3 patients from Dukes* B to C. In all patients categorized as Nx (regional lymph nodes not assessed) by the traditional method, lymph nodes were detected after employment of LNRS. The mean diameter of dissected lymph nodes was significantly smaller than the traditional method (0.268 versus 0.429, p< 0.000001). LNRS in comparison with previous solutions is inexpensive, rapid and easy to use. We propose use of this solution in all Dukes* B and patients with no lymph node detection by traditional method.
 
Keyword(s): LYMPH NODE REVEALING SOLUTION, COLORECTAL CARCINOMA, METASTATIC LYMPH NODE
 
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