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Paper Information

Journal:   ACTA MEDICA IRANICA   2004 , Volume 42 , Number 2; Page(s) 78 To 82.
 
Paper: 

EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE

 
 
Author(s):  JAMSHIDI H.R., REZAYAT M., ZARINDAST M.R.
 
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Abstract: 
In the present study, the effect of apamin (potassium channel blocker) on tolerance to
cocaine-induced locomotor activity in mice has been investigated. Locomotor activity was measured by locomotor activity meter, Animax, type S (LKB, Farrad). Intraperitoneal (IP) injection of different doses of cocaine (2.5, 5, 10 and 15 mg/kg) produced dose-dependent locomotor activity in mice.Animals were treated with a dose of cocaine (60 mg/kg, IP) once daily, for 2, 3 or 4 days in order to produce tolerance to cocaine-induced locomotion. Twenty-four hours after the last dose of cocaine, locomotor activity induced by a test dose of cocaine (10 mg/kg) was assessed. Animals pretreated with apamin (0.1 mg/kg) 30 min before the test dose of cocaine had a decreased cocaine response. However, daily treatment of animals with apamin (0.1 mg/kg), 30 min after cocaine (60 mg/kg) for 3 days (during development of tolerance to cocaine-induced locomotion), did not alter the cocaine effect. Single administration of apamin to mice did not cause any response. It is concluded that, apamin as a potassium channels blocker may decrease tolerance to cocaine-induced locomotion due to blockade of potassium channels.
 
Keyword(s): COCAINE , APAMIN , TOLERANCE , LOCOMOTOR ACTIVITY , MICE
 
 
References: 
 
Cite:
APA: Copy

JAMSHIDI, H., & REZAYAT, M., & ZARINDAST, M. (2004). EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE. ACTA MEDICA IRANICA, 42(2), 78-82. https://www.sid.ir/en/journal/ViewPaper.aspx?id=13754



Vancouver: Copy

JAMSHIDI H.R., REZAYAT M., ZARINDAST M.R.. EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE. ACTA MEDICA IRANICA. 2004 [cited 2021April17];42(2):78-82. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13754



IEEE: Copy

JAMSHIDI, H., REZAYAT, M., ZARINDAST, M., 2004. EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE. ACTA MEDICA IRANICA, [online] 42(2), pp.78-82. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=13754>.



 
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