Paper Information

Journal:   ACTA MEDICA IRANICA   2004 , Volume 42 , Number 3; Page(s) 198 To 204.
 
Paper: 

EFFECT OF CIMETIDINE AND RANITIDINE ON LIPID PROFILE AND LIPID PEROXIDATION IN ?-IRRADIATED MICE

 
 
Author(s):  KABOUDANIAN ARDESTANI S., MAHMOOD JANLOW M., KARIMINIA AMINA, TAVAKOLI Z.
 
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Abstract: 
Elevated amounts of free radicals due to ionizing radiation have damaging effects on the body. H2-receptor antagonists have potential oxygen radical scavenging properties. We tried to determine the effects of two H2-receptor antagonists (cimetidine and ranitidine) on lipid peroxidation (LPO) and lipid profile (LP) in plasma and liver of ?-irradiated (1Gy/day for 3 days) BALB/c mice. The control group of mice were fed with normal food and drinks but the experiment group of mice were fed control diet and drinking water, containing cimetidine or ranitidine (1mg/lit). After 3 days of supplementation, the animals were subjected to sublethal ?-radiation, which caused a significant increase in cholesterol level in experimental group (100% increase in comparison with the control group), but the amount of phospholipids did not change. The ratio of cholesterol to phospholipid showed a slight increase. Also ?-irradiation caused a significant increase in lipid fluorescence (11-48%), conjugated dienes (33-81%) in liver and increase in malondialdehyde (19-300%) in serum of mice who had received 1.09-3.1 Gy for 1-3 days. Cimetidine or ranitidine supplementation was able to restore the changes of LPO and LP in mice (1 Gy-radiated for 3 days). It is therefore concluded that the mice treated with cimetidine or ranitidine were able to tolerate biomembrane damages provoked by sublethal ?-radiation. This supports the hypothesis that cimetidine or ranitidine may afford an efficient protection against ionizing radiation or diseases that are characterized by in vivo free radical-mediated oxidative stress mechanisms.
 
Keyword(s): ? , -IRRADIATION , BALB/C MICE , LIPID PROFILE , LIPID PEROXIDATION , H2-RECEPTOR ANTAGONIST
 
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