Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   May-June 2003 , Volume 8 , Number 2; Page(s) 6 To 10.
 
Paper: 

MODELLING 2X2 CROSS-OVER DESIGNS WITH CARRY-OVER EFFECT FOR BINARY RESPONSES

 
 
Author(s):  JAHANI HASHEMI H.*, KAZEMNEJAD ANOUSHIRAVAN, GANJALI M., AMINI MASOUD, FAGHIHZADEH S.
 
* Medical Sciences Universityof Qazvin
 
Abstract: 

In Parallel designs which each patient receives only one treatment we need a large number of patients for assessing treatment effects. Cross-over trials are Known as longitudinal studies.In cross-over trials each patient is his or her own control and hence it is possible to make more precise result, that is, small number of patients is sufficient. In modelling cross-over designs two important issues must be considered: (i) carry-over effect (H) correlated responses for each patient. In this paper, by using generalized linear models (GLM), we present a transition (Markov) model for binary responses which enables us take into account two important issues simultaneously.

 
Keyword(s): CARRY-OVER EFFECT, CROSS-OVER DESINGS, LONGITUDINAL STUDIES, GENERALIZED LINER MODELS (GLM), TRANSITION (MARKOV) MODEL, CORRELATED RESPONSES, WASH-OUT PERIOD, LOGIT
 
References: 
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