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Paper Information

Journal:   JOURNAL OF MILITARY MEDICINE   WINTER 2003 , Volume 4 , Number 4; Page(s) 301 To 307.
 
Paper: 

EFFECT OF ACUTE AND SUBACUTE LEAD EXPOSURE ON RESPONSIVENESS OF ADRENERGIC SYSTEM IN RAT

 
 
Author(s):  HEYDARI A., NOUROUZZADEH ALI, KARIMI G.R., DEHPOUR A.R., TABAEI S., ZARINDAST M.R., KHOUSHBATEN A., ASGARI A.
 
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Abstract: 
Lead exposure can induce hypertension in human and experimental animals. The exact mechanism of lead-induced hypertension is unknown but many factors such as changes in responsiveness of adrenergic system may be involved. In this study the effects of acute and subacute lead exposure (28 days) on responsiveness of thoracic aorta were investigated. Sprague Dawley rats (200-250 gr) were used. After removal of thoracic aorta and placing in ice-cold Krebs solution, fatty and-connective tissue was cleaned. Aortic rings (2-3 mm) were sectioned and mounted in tissue baths for the measurement of isometric contraction. The tissue baths contained 10ml Krebs solution at 37°C and gassed with %95 O2/ %5 CO2.Aorta rings were placed under optimal resting force of 2 gr for 45 min, and then exposed twice to 40-mmol/l KCl. The contraction response to the second exposure to KCl was taken as reference for other calculations. The contractile responses were evaluated by adding incremental doses of different factors such as phenylephrine, prazosin, clonidine, yohimbine, dopamine and SCH in the presence or absence ofL-NAME and indomethacin. The results showed that acute and subacute lead exposure significantly increases contractile response. It also seems that adrenergic system is not solely responsible for this effect and other factors such as changes in Ca?+exchange, nitric oxide and cyclooxygenase rout may be involved.
 
Keyword(s): LEAD ACETATE; HYPERTENSION; ADRENERGIC SYSTEM; ENDOTHELIUM; L-NAME; INDOMETHACIN
 
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