Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   Ocrober-November 2003 , Volume 8 , Number 4; Page(s) 25 To 29.
 
Paper: 

THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT

 
 
Author(s):  SHAFIEE K.*, BAREKATEYN M., BASHARDOUST N.A., MAHMOUDI J.
 
* Department of Psychiatry, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
 
Abstract: 

Introduction: Acheiving accelerated clinical response is desirable in patients with acute manic episode. We conducted a prospective study to compare the rate of clinical response of oral loading sodium valproate versus standard dose titration.
Methods: Fourty - two patients who met DSM - IV critevia for current manic episode and who had a "Young mania rating scale "score between 20 and 50 were randomly assigned on a double blind basis to recieve valproate oral "loading"(N=21) at a dose of 20 mg/kg in divided doses for 7 days and valproate "non -loading" at a starting dose of 10 mg/kg followed by standard titration which at day 6 , they recieved 20 mg/kg valproate. Patients were scored at day 0, 3, 5 and 7 by a blindraterusing YMRS.
Results: There was no significat differences between the groups in advers events and useing of adjunctive tranquilizer .The efficacy of valproate in both two groups was similar but " the rate of improvement on YMRS" over the first 3 days was significantly greater in loading group.
Conclusion: Valproate oral loading with sodium valproate can induced a more rapid clinical response in acutely manic patient.

 
Keyword(s): ACUTE MANIC EPISODE, DSM, IV,SODIUM VALPROATE, YOUNG MANIA RATING SCALE
 
References: 
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