Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   Ocrober-November 2003 , Volume 8 , Number 4; Page(s) 25 To 29.
 
Paper: 

THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT

 
 
Author(s):  SHAFIEE K.*, BAREKATEYN M., BASHARDOUST N.A., MAHMOUDI J.
 
* Department of Psychiatry, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
 
Abstract: 

Introduction: Acheiving accelerated clinical response is desirable in patients with acute manic episode. We conducted a prospective study to compare the rate of clinical response of oral loading sodium valproate versus standard dose titration.
Methods: Fourty - two patients who met DSM - IV critevia for current manic episode and who had a "Young mania rating scale "score between 20 and 50 were randomly assigned on a double blind basis to recieve valproate oral "loading"(N=21) at a dose of 20 mg/kg in divided doses for 7 days and valproate "non -loading" at a starting dose of 10 mg/kg followed by standard titration which at day 6 , they recieved 20 mg/kg valproate. Patients were scored at day 0, 3, 5 and 7 by a blindraterusing YMRS.
Results: There was no significat differences between the groups in advers events and useing of adjunctive tranquilizer .The efficacy of valproate in both two groups was similar but " the rate of improvement on YMRS" over the first 3 days was significantly greater in loading group.
Conclusion: Valproate oral loading with sodium valproate can induced a more rapid clinical response in acutely manic patient.

 
Keyword(s): ACUTE MANIC EPISODE, DSM, IV,SODIUM VALPROATE, YOUNG MANIA RATING SCALE
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

SHAFIEE, K., & BAREKATEYN, M., & BASHARDOUST, N., & MAHMOUDI, J. (2003). THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 8(4), 25-29. https://www.sid.ir/en/journal/ViewPaper.aspx?id=13564



Vancouver: Copy

SHAFIEE K., BAREKATEYN M., BASHARDOUST N.A., MAHMOUDI J.. THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS). 2003 [cited 2021June15];8(4):25-29. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13564



IEEE: Copy

SHAFIEE, K., BAREKATEYN, M., BASHARDOUST, N., MAHMOUDI, J., 2003. THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), [online] 8(4), pp.25-29. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13564.



 
 
Persian Abstract Yearly Visit 44
 
 
Latest on Blog
Enter SID Blog