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Paper Information

Journal:   JOURNAL OF MILITARY MEDICINE   Fall 2003 , Volume 5 , Number 3; Page(s) 227 To 232.
 
Paper: 

GENETICALLY MODIFIED BIOLOGICAL AGENTS AND THEIR HIDDEN HAZARDS

 
 
Author(s):  RANJBAR REZA*
 
* Baghyatollah(a.s) University of Medical Sciences, Militaty Medicine Institute, Recearch Center of Biology, Tehran, Iran
 
Abstract: 

New revolution in biology began in the 1970s with a set of techniques known as genetic engineering, or recombinant DNA technology and has since been expanded by development of rapid DNA sequencing technology. These techniques are similar to a two-edged sword. While providing an increasing number of methods for producing of biotechnologies products such as foods, drugs and vaccines, although shed new light on methods to producing genetically modified or transgenic organisms. The potential types of novel biological agents that could be produced through genetic engineering are new microorganisms that have never exited; benign microorganisms, genetically altered to produce a toxin, or bio regulator; microorganisms with increased pathogenicity; microorganisms resistant to antibiotics, standard vaccines and therapeutics; immunologically altered microorganisms able to defeat standard identification, detection and diagnostic methods; microorganisms with altered antigenic structures; microorganisms with enhanced aerosol, environmental stability; and microorganisms that specifically harm certain target populations. For producing of genetically modified organisms, genetic engineers apply horizontal gene transfer techniques. They have made a huge variety of artificial constructs to cross species barriers and to invade genomes. The artificial constructs or transgenic DNA typically contain genetic material from bacteria, viruses and other genetic parasites. These constructs are structurally unstable and enhance horizontal gene transfer. Horizontal gene transfer may spread transgens to entire biosphere.

 
Keyword(s): GENETICALLY MODIFIED BIOLOGICAL AGENTS, RECOMBINANT DNA, HORIZONTAL GENE TRANSFER
 
References: 
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