Paper Information

Journal:   JOURNAL OF MILITARY MEDICINE   Fall 2003 , Volume 5 , Number 3; Page(s) 211 To 217.
 
Paper: 

HISTOPATHOLOGIC CHANGES IN LUNG RAT OF THE ACUTE AND CHRONIC EXPOSURE SULFUR MUSTARD

 
 
Author(s):  MAHDAVINASAB H., MOFID. M., EIMANI. H., ASADI M.A., BAHADORAN H., MIRSHAFIEI GH.A.
 
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Abstract: 

The aim of this study evaluated the effects of sulfure mustard (SM) on alveolar, lung aranchym and designed lung chemical agent exposure animal model. Seventhly eight NMRI 3 months old Rats (weight 200±40g) were selected and randomly divided groups sham, control and Experimental based on duration of exposure and dosage of intraperitoneal injection (JP). Sham and groups received thyroids buffer (sulfur mustard solution) or nothing respectively. Five groups received once different doses of SM (2.5/5/10/20/40 mg/kg). All experimental groups, for evaluation of subacute and chronic stage, different doses of SM injected and after 24 hours, 2 weeks and 8 weeks misecared. Dissected and 5 samples were taken from right lung tissue. All samples were fixed, embedded in parafin wax and serially sectioned in 5 micron pieces by microtome. Then they were stained by Hematoxylin and Eosin. These results showed that the effects of SM an alveolar and paranchym depend on doses and remain for along time. Among experiments groups, Lesion of alveolar structure and paranchym were the highest than sham and control groups too. Depending on doses, Histopathological changes such as edema, inflammation and hemorrhage (Less in 2.5mg/kg and highest in 40mg/kg) were observed.
In conclusion: This result showed that, the SM exposure lung rat good animal model for study of effects of SM on lung tissue.

 

 
Keyword(s): SULFUR MUSTARD, LUNG PARANCHYM, RAT
 
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