Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2004 , Volume 62 , Number 8; Page(s) 685 To 689.
 
Paper: 

THE EFFECT OF HYPERGLYCEMIA ON THE SEIZUR THRESHOLD INDUCED BY PTZ IN MICE

 
 
Author(s):  SAMINI M., SHAIAN MEHR A., SHAFAROUDI H.
 
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Abstract: 

Background: we studied the effect of hyperglycemia on the seizure threshold to PTZ in mice. Materials and Methods: In control group PTZ injected via the tail vein 30 min after saline injection. In test group glucose 40% was used via gastric gavage and the hyperglycemia was approved by determination of plasma glucose concentration.
Results: In control group plasma glucose was 300.93 mg/dl showing a significant difference in comparison with test group 97.15 mg/dl (P<0.001). After induction of hyperglycemia we determined the seizure threshold induced by PTZ.
Conclusion: In conclusion, our results showed that in hyperglycemic mice the seizure threshold to PTZ is reduced, probably because of decreasing the GABA activity in the CNS.

 
Keyword(s): HYPERGLYCEMIA, SEIZURE THRESHOLD, PTZ, GABA ACTIVITY
 
References: 
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