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Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2004 , Volume 62 , Number 8; Page(s) 685 To 689.
 
Paper: 

THE EFFECT OF HYPERGLYCEMIA ON THE SEIZUR THRESHOLD INDUCED BY PTZ IN MICE

 
 
Author(s):  SAMINI M., SHAIAN MEHR A., SHAFAROUDI H.
 
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Abstract: 

Background: we studied the effect of hyperglycemia on the seizure threshold to PTZ in mice. Materials and Methods: In control group PTZ injected via the tail vein 30 min after saline injection. In test group glucose 40% was used via gastric gavage and the hyperglycemia was approved by determination of plasma glucose concentration.
Results: In control group plasma glucose was 300.93 mg/dl showing a significant difference in comparison with test group 97.15 mg/dl (P<0.001). After induction of hyperglycemia we determined the seizure threshold induced by PTZ.
Conclusion: In conclusion, our results showed that in hyperglycemic mice the seizure threshold to PTZ is reduced, probably because of decreasing the GABA activity in the CNS.

 
Keyword(s): HYPERGLYCEMIA, SEIZURE THRESHOLD, PTZ, GABA ACTIVITY
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

SAMINI, M., & SHAIAN MEHR, A., & SHAFAROUDI, H. (2004). THE EFFECT OF HYPERGLYCEMIA ON THE SEIZUR THRESHOLD INDUCED BY PTZ IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(8), 685-689. https://www.sid.ir/en/journal/ViewPaper.aspx?id=13482



Vancouver: Copy

SAMINI M., SHAIAN MEHR A., SHAFAROUDI H.. THE EFFECT OF HYPERGLYCEMIA ON THE SEIZUR THRESHOLD INDUCED BY PTZ IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ). 2004 [cited 2021June17];62(8):685-689. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13482



IEEE: Copy

SAMINI, M., SHAIAN MEHR, A., SHAFAROUDI, H., 2004. THE EFFECT OF HYPERGLYCEMIA ON THE SEIZUR THRESHOLD INDUCED BY PTZ IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), [online] 62(8), pp.685-689. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13482.



 
 
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