Paper Information

Journal:   JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH   Summer 2003 , Volume 11 , Number 43; Page(s) 17 To 23.
 
Paper: 

GESTATIONAL DIABETES MELLITUS DIAGNOSED WITH A 75-GRAM ORAL GLUCOSE TOLERANCE TEST AND ADVERSE PREGNANCY OUTCOMES

 
 
Author(s):  KAMALI S., SHAHNAM F., POORMEMARI MH.
 
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Abstract: 

Background: There is a general consensus that the prevalence of gestational diabetes mellitus (GDM) is increasing globally, but there is considerable controversy about the screening method of this entity. So, this study was performed to indicate the relationship between the screening for the gestational diabetes with a 75-gram oral glucose tolerance test and the outcome of the pregnancy.
Materials and Methods: In this descriptive study a total of 450 qualified pregnant women who received prenatal cares were selected by convenience method. Collecting data were performed through the interviewing and studying their medical history. A 75 g oral glucose tolerance test was performed for all the pregnant women at 24-28 weeks of gestation. The subjects who had two or more abnormal blood plasma glucose based on ADA criteria were known as gestational diabetic individuals. All subjects were followed until delivery and their pregnancy outcomes were recorded. Fisher Exact test and chi-square test were used for data analysis.
Results: In this study, 2.9% of the subjects had positive screening test for GDM. There was a significant relationship between the positive test and the adverse pregnancy outcomes including congenital abnormalities, macrosomia, preeclampsia/eclampsia and preterm labor. However, there was no relationship between the positive test and the still birth. In addition, there was a significant relationship between the positive test and the age, weight, BMI, gravity, glucosuria, fasting blood sugar and also the history of the abortion, preterm labor, still birth, macrosomia, and familial diabetes. There was no relationship between the positive test and the history of abnormal infant and history of the GDM in previous pregnancies.
Conclusion: Since there is a significant relationship between the positive results with 75-g oral glucose tolerance test and the adverse pregnancy outcomes we suggest that the screening test with 75-g glucose can be used for screening of GDM at least in high risk women.

 
Keyword(s): GESTATIONAL DIABETES MELLITUS, SCREENING, 75-GRAM GLUCOSE, TOLERANCE TEST
 
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