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Paper Information

Journal:   JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH   Winter 2002 , Volume 10 , Number 41; Page(s) 15 To 21.
 
Paper: 

PROTECTIVE EFFECT OF ALCOHOL ON MUSCLE PARALYSIS INDUCED BY ATRACORIUM

 
 
Author(s):  MOGHADAMNIA ALI AKBAR, BISHEH SARI NIMA
 
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Abstract: 

Introduction: Regarding to the side effects of muscle relaxants specially non - depolarizing agents, this study was done to determine the protective effect of alcohol on muscle paralysis induced by atracorium in preparation of isolated chicken biventer cervices muscle.
Materials and methods: This experimental study was performed on two groups of chicken biventer cervices muscle. In each group, 6 chickens were recruited. After inserting the muscles in organ bath containing Tirod physiologic solution and oxygen at 37°c, atracorium was introduced to the first group. A combination of alcohol and atracorium was added to the second group. Percent of muscle paralysis and duration of contraction in each group was then registered. Student t-test was performed for analysis of the data.
Results: Percent of muscle paralysis followed by atracorium introduction in chick biventer cervices muscle was decreased in the presence of ethanol (p<0.01). Duration of paralysis was decreased also in the group receiving ethanol compared with the group receiving atracorium alone (p<0.01).
Conclusion: Results suggested that ethanol with possible presynaptic and postsynaptic effects can protect the muscle against the paralysis induced by atracorium.

 
Keyword(s): ETHANOL, ATRACORIUM, MUSCLE PARALYSIS
 
References: 
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