Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2004 , Volume 62 , Number 7; Page(s) 580 To 584.
 
Paper: 

COMPARATIVE EFFICACY OF CEFTRIAXONE AND NALIDIXIC ACID IN CHILDHOOD SHIGELLOSIS BAHRAMI HOSPITAL, 2002-2003

 
 
Author(s):  RAHBARIMANESH A.A., ZOGHI J.
 
* 
 
Abstract: 

Background: The efficacy of oral nalidixic acid was compared with intravenous cefriaxone in the treatment of acute shigellosis in children 6 mo-12 yrs old of age.
Materials and Methods: In a randomized clinical trial (single blind) we studied 110 comparable patient admitted in Bahrami hospital with primary diagnosis of shigellosis (clinically suggested of shigellosis and confirmed by stool culture) at 2002-2003. Patients were randomly assigned to receive either intravenous ceftriaxone 50 mg/kg/day single dose for 2 days or nalidixic acid 55 mg/kg/day in divided doses for 5 days orally.
Results: In the results, there was not any statistically significant difference in the diarrhea resolving period, fever resolving period, hospitalization period, negativation of sic and prevalence of shigellosis complications in the course of treatment between two groups. Conclusion: According to results, nalidixic acid is effective and safe as well as ceftriaxone in the treatment of acute childhood shigellosis. However we recommended, "nalidixic acid" is a good substitution for treatment of uncomplicated childhood shigellosis.

 
Keyword(s): SHIGELLOSIS, CEFTRIAXONE, NALIDIXIC ACID
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 50
 
Latest on Blog
Enter SID Blog