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Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2004 , Volume 62 , Number 5; Page(s) 389 To 393.
 
Paper: 

PREVALENCE OF COELIAC DISEASE IN UNEXPLAINED INFERTILITY AND COMPARISON WITH CONTROL GROUP (SHARIATI HOSPITAL 1380-1381)

 
 
Author(s):  ALE YASIN ASHRAF, FROOTAN M.I., FROOTAN M.O., AKBARI M.R., AGHAHOSSEINI M., SOTOUDEH M., MALEKZADEH R.
 
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Abstract: 

Background: Infertility is a problem in health and economy system of Iran and in 10-15% of case major we cannot find any specific etiology. Prevalence of celiac diseasein Iran is 1/166 in asymptomatic blood donor. This disease has a wide range of clinical features. Recurrent abortion and infertility is a one side of this range. In recent studies there is relationship between celiac disease and unexplained infertility. So in this study we will show the prevalence of celiac disease in unexplained infertility in Iranian patients.
Materials and Methods: This case-control study include 125 patients with primary unexplained infertility and 125 fertile women as control. In patients whom came to Shariati Hospital, infertility clinic and have criteria of our study we measure total IgA, IgA TTG (Bio system Spain) if TTG was positive to prove our study, we did biopsy of distal duodenum. For control group 125 patient that have two or more children with similar. .. with infertile group selected. Results: In four infertile patient unexplained infertility, 3% have positive TTG and in three of them (2.4%), biopsy of small intestine has shown celiac disease none of the women in control group had positive TTG (p=O.08). Conclusion: It seems that in some of the Iranian patients with unexplained infertility have celiac diseases. But with the P=0.08 in comparison to control group the screening for infertile PTs with unexplained infertility needs a wider study with more samples.

 
Keyword(s): INFERTILITY, CELIAC DISEASE, TIG
 
References: 
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