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Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2004 , Volume 62 , Number 5; Page(s) 384 To 388.
 
Paper: 

TREATMENT WITH ALENDRONATE, CALCIUM AND VITAMIN D IN OSTEOPOROSIS AND OSTEOPENIA

 
 
Author(s):  EBRAHIM ZADEH S.A.R., RAHIMI HAJIABADI M.
 
* 
 
Abstract: 

Background: Osteoporosis is the most common bone disease and is a leading cause of morbidity and mortality in elderly people. Multiple therapeutic regimens have been designed to prevent progressive bone loss in postmenopausal women and the elderly and to treat reduced bone mass by inhibiting bone resorbption and/or increasing bone formation. Although Monotherapy is preferred but combination therapy is recommended in many studies. In this study we used Alendronate, calcium &vitamin D and measured its effectiveness.
Materials and Methods: We chose 47 patients who had osteoporosis and osteopenia complications and took them a combined Regimen of Alendronate, calcium supplement and vitamin D and had been advised to have regular exercise. We measured their BMD and T- score at beginning and end of the study.
Results: After 12.7
± 1.27 month BMD and T- score changed dramatically in our patients. They have 1.29 ± 4.22 percent increase in BMD of pelvis, 2.6 ± 4.86 percent in vertebra. T-score was increased 0.152 ±0.3 in vertebra and 0.84± 0.36 in Pelvis.
Conclusion: Osteoporosis is a disorder of bone characterized by reduced mineral density and bone mass. Multiple therapeutic regimens have been recommended to prevent and treatment it. In our study, we found that combined Regimen of Alendronate, calcium supplement and vitamin D is effective in treatment osteoporosis and recommend it if economical and medical conditions of patients allow it.

 
Keyword(s): OSTEOPOROSIS, ALENDRONATE, VITAMIN D
 
References: 
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