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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   2004 , Volume 33 , Number 2; Page(s) 60 To 65.
 
Paper: 

EVALUATION OF TRICHOMONAS VAGINALIS ISOLATES FROM SYMPTOMATIC AND ASYMPTOMATIC PATIENTS IN MOUSE MODEL

 
 
Author(s):  VALADKHANI Z.T.*, SHARMA S., HARJAI K., GUPTA I., MALLA N.
 
* DEPT. OF PARASITOLOGY, PASTEUR INSTITUTE OF IRAN, TEHRAN, IRAN
 
Abstract: 
Trichomoniasis, a worldwide prevalent infection, is a perfect example of interplay between the infecting parasite and the host, on which the presentation of disease depends. To study the pathogenesis, animal model is required for establishment of infection. In this study, by using strains of Trichomonas vaginalis isolated from vaginal swabs and/or urine samples and maintained in axenic form from 10 symptomatic and 10 asymptomatic female patients, the infections in BALB/c mice have been evaluated. Based on parasitic load, experimental peak infection in vagina of estradiol and L. acidophilus treated female BALB/c mice was observable on 5th post infection day. This was significantly higher in mice infected with isolates from symptomatic patients in comparison to the other group. Gradual increase up to day 5 followed by decline in parasites, polymorphs and vaginal epithelial cells was observed in mice infected with isolates from symptomatic subjects in contrast to mice infected with asymptomatic patients’ isolates or control animals at all time intervals.
 
Keyword(s): TRICHOMONIASIS VAGINALIS, ANIMAL MODEL, LACTOBACILLI, IRAN
 
References: 
 
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