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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)   March 2004 , Volume 29 , Number 1; Page(s) 26 To 30.
 
Paper: 

THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B

 
 
Author(s):  ZAHED MEHR A., DELMAGHANI S., SHARIFIAN R., LAK M., ZEYNALI S.*
 
* Tehran, Iran
 
Abstract: 
Background: Hemophilia B is an X-linked recessive coagulation disorder caused by factor IX deficiency. Analysis of factor IX gene polymorphisms is considered the best approach for prenatal diagnosis and carrier detection of hemophilia B where the identification of gene mutation is not easily possible. Objective: To study the frequency of three factor IX-linked restriction fragment length polymorphisms (RFLPs) in Iranian women.
Methods: 50 normal women and 50 mothers of patients with hemophilia B entered this study. RFLP/Polymerase chain reaction (PCR) techniques for detection of BamHI, HhaI and MnlI sites were used.
Results: The frequencies of DNA polymorphisms were 0.50/0.50 for HhaI; 0.24/0.76 for MnlI; and 0.02/0.98 for BamHI sites. Among 9 different haplotypes, 2 major haplotypes were predominated.
Conclusion: HhaI and MnlI RFLPs can be used for carrier detection and prenatal diagnosis of hemophilia B.
 
Keyword(s): HEMOPHILIA B • RESTRICTION FRAGMENT LENGTH POLYMORPHISMS • FACTOR IX
 
 
References: 
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Citations: 
 
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APA: Copy

ZAHED MEHR, A., & DELMAGHANI, S., & SHARIFIAN, R., & LAK, M., & ZEYNALI, S. (2004). THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 29(1), 26-30. https://www.sid.ir/en/journal/ViewPaper.aspx?id=13148



Vancouver: Copy

ZAHED MEHR A., DELMAGHANI S., SHARIFIAN R., LAK M., ZEYNALI S.. THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS). 2004 [cited 2021June13];29(1):26-30. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13148



IEEE: Copy

ZAHED MEHR, A., DELMAGHANI, S., SHARIFIAN, R., LAK, M., ZEYNALI, S., 2004. THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), [online] 29(1), pp.26-30. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13148.



 
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