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Paper Information

Journal:   ARCHIVES OF RAZI INSTITUTE   December 2002 , Volume - , Number 54; Page(s) 77 To 84.
 
Paper: 

HUMORAL IMMUNE RESPONSE TO MUMPS (RS-12 STRAIN) VACCINE OF CHILDREN 1-7 YEARS OLD

 
 
Author(s):  ASNA ASHARI F.*, MIRCHAMCY H., SHAFIEI A., SHAMS SHAHRABADI M., SABIRY G.M., SASSANI A., HOSSEINZADEH T.
 
* HUMAN VIRAL DISEASES VACCINES RESEARCH & PRODUCTION DEPT., RAZI VACCINE & SERUM RESEARCH INSTITUE, TEHRAN, IRAN
 
Abstract: 

The immunogeneticity of monovalent mumps vaccine, in order to conferring long time immunity against the wild virus, prepared from RS-12 local strain was evaluated. The paired serum samples were collected from a total of 160 children before and after vaccination against mumps with the monovalent vaccine. From these children, 156 ones showed an increased anti hemmaglutinin antibody by HI test. The geometric mean titer (loge) was calculated 3.04 from 96 seronegative -cases, 95 of them were produced detectable antibodies. Seroconversion of RS-12 strain is estimated 99%. Booster effect of the vaccine is confirmed by 4-fold increasing in HI titer in 64 seropostitive cases. Increasing of immune case up to 140 (87%) is the other reason for effectiveness of the vaccine. Consequently RS-12 attenuated strain can be a suitable candidate for production of monovalent mumps and polyvalent vaccines, in combination with the other infectious agents, which set up on conventional vaccination program.

 
Keyword(s): MUMPS, VACCINATION, IMMUNIZATION, SN TEST, AND HI TEST
 
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