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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)   September 2004 , Volume 29 , Number 3; Page(s) 130 To 133.
 
Paper: 

EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT

 
 
Author(s):  FALAHZADEH M.H.*, NOURAFSHAN A., TANIDEH N., BADELI H.R., BAZARGANI A.
 
* DEPARTMENT OF PEDIATRICS, NAMAZEE HOSPITAL, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES SHIRAZ, IRAN
 
Abstract: 
Background: Pyelonephritis can lead to renal scar. Objective: To evaluate the effects of betamethasone in preventing renal scarring in rat model of pyelonephritis.
Methods: Sixty three female Sprague-Dawley rats were divided into seven groups. Group A was the control. Mannosesensitive E coli was directly inoculated into the left kidney exposed under general anesthesia in groups C–G. Group B received normal saline. Two days after bacterial inoculation, groups C, E and F received gentamicin for 10 days. Betamethasone was injected for three days to animals in groups of D, E (2 days after bacterial inoculation) and F (5 days after bacterial inoculation). Group G received no treatment. Eight weeks after bacterial inoculation, animals were sacrificed and the volume (amount) of renal scar was determined using the stereological techniques.
Results: Changes in the weight and volume of the kidneys were not statistically significant. No scar was detected in group A, but all other groups including group B with intrarenal injections showed scarring. The volume density and absolute volume of the scar in groups C–G were significantly more than group B (p<0.001), whereas they did not differ significantly from each other.
Conclusion: Betamethasone and/or gentamicin, when used two days after induction of pyelonephritis were not effective in preventing renal scar.
 
Keyword(s): PYELONEPHRITIS , RENAL SCAR , BETAMETHASONE ,GENTAMICIN , RAT
 
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