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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)   September 2004 , Volume 29 , Number 3; Page(s) 130 To 133.
 
Paper: 

EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT

 
 
Author(s):  FALAHZADEH M.H.*, NOURAFSHAN A., TANIDEH N., BADELI H.R., BAZARGANI A.
 
* DEPARTMENT OF PEDIATRICS, NAMAZEE HOSPITAL, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES SHIRAZ, IRAN
 
Abstract: 
Background: Pyelonephritis can lead to renal scar. Objective: To evaluate the effects of betamethasone in preventing renal scarring in rat model of pyelonephritis.
Methods: Sixty three female Sprague-Dawley rats were divided into seven groups. Group A was the control. Mannosesensitive E coli was directly inoculated into the left kidney exposed under general anesthesia in groups C–G. Group B received normal saline. Two days after bacterial inoculation, groups C, E and F received gentamicin for 10 days. Betamethasone was injected for three days to animals in groups of D, E (2 days after bacterial inoculation) and F (5 days after bacterial inoculation). Group G received no treatment. Eight weeks after bacterial inoculation, animals were sacrificed and the volume (amount) of renal scar was determined using the stereological techniques.
Results: Changes in the weight and volume of the kidneys were not statistically significant. No scar was detected in group A, but all other groups including group B with intrarenal injections showed scarring. The volume density and absolute volume of the scar in groups C–G were significantly more than group B (p<0.001), whereas they did not differ significantly from each other.
Conclusion: Betamethasone and/or gentamicin, when used two days after induction of pyelonephritis were not effective in preventing renal scar.
 
Keyword(s): PYELONEPHRITIS , RENAL SCAR , BETAMETHASONE ,GENTAMICIN , RAT
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

FALAHZADEH, M., & NOURAFSHAN, A., & TANIDEH, N., & BADELI, H., & BAZARGANI, A. (2004). EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 29(3), 130-133. https://www.sid.ir/en/journal/ViewPaper.aspx?id=13099



Vancouver: Copy

FALAHZADEH M.H., NOURAFSHAN A., TANIDEH N., BADELI H.R., BAZARGANI A.. EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS). 2004 [cited 2021June12];29(3):130-133. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13099



IEEE: Copy

FALAHZADEH, M., NOURAFSHAN, A., TANIDEH, N., BADELI, H., BAZARGANI, A., 2004. EFFECTS OF BETAMETHASONE AND GENTAMICIN ON RENAL SCARRING INDUCED BY MANNOSE-SENSITIVE E COLI PYELONEPHRITIS IN RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), [online] 29(3), pp.130-133. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13099.



 
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