Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   October 2002 , Volume 5 , Number 4; Page(s) 259 To 261.
 
Paper: 

GONADOBLASTOMA: A CLINICOPATHOLOGIC STUDY

 
 
Author(s):  IZADI MOUD N., AZORDEGAN N.
 
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Abstract: 
Gonadoblastoma is a rare tumor found almost exclusively in patients with an underlying gonadal disorder, and accounts for two-thirds of gonadal tumors in women with abnormal gonadal development. Three cases of gonadoblastoma are reported here. One had Swyer syndrome (pure gonadal dysgenesis) with a 46-XY karyotype, the second patient had a mixed 46-XY and 46-XO karyotype, and the third patient had male pseudohermaphrodism and a 46-XY karyotype. Patients with pure gonadoblastoma have an excellent prognosis, when bilateral excision is performed. Gonadoblastoma may be overgrown by dysgerminoma, however, there is a good prognosis. Gonadoblastoma has never been detected with metastatic lesions. The prognosis for gonadoblastoma, including cases of Swyer syndrome, is good, provided early excision is performed bilaterally.
 
Keyword(s): DYSGERMINOMA - GONADAL DYSGENESIS - GONADOBLASTOMA - SWYER SYNDROME
 
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