Paper Information

Journal:   JOURNAL OF MEDICAL COUNCIL OF I.R.I.   FALL 2004 , Volume 22 , Number 3; Page(s) 220 To 226.
 
Paper: 

EVALUATION OF CHIMERISM IN INTERPHASE NUCLEI OF PERIPHERAL BLOOD OF PATIENTS WITH SEXMISMATCH BONE MARROW TRANSPLANTATION

 
 
Author(s):  GHAFARI H., GHASHGHAEI A., KAMALI MOGHADAM K., GHAVAMZADEH ARDESHIR
 
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Abstract: 

Fully quantitative cytological techniques for the analysis of hematopoietic chimerism are very limited and are largely restricted to sex - chromosome detection after sex - mismatched bone marrow transplants (BMTs). The aim of the present investigation was to evaluate the application of FISH technique in peripheral blood interphase nuclei of three patients who had received sex - mismatched bone marrow transplants. The FISH technique shows 40% to 85%(average 61%) chimerism in these patients. All the three studied patients having undergone bone marrow transplants have achieved complete remission now. Evaluation of mixed chimerism has potential applications in controlling self reactions avoiding rejection of the transplant.

 
Keyword(s): CHIMERISM, SEX- MISMATCHED BONE MARROW TRANSPLANTATION, FISH
 
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