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Paper Information

Journal:   JOURNAL OF MEDICAL COUNCIL OF I.R.I.   FALL 2004 , Volume 22 , Number 3; Page(s) 215 To 219.
 
Paper: 

EVALUATION OF THE RELATION SHIP BETWEEN OVARIAN DYSGERMINOMAS AND THE RESULTS OF DNA ANALYSIS

 
 
Author(s):  IZADI MOUD N., MOUSAVI A., NIASARI M., DADKHAH F.
 
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Abstract: 

This paper studies the relationship of DNA analysis ploidy and stage of ovarian dysgerminoma and its prognosis with flowcytometric evaluation. The files and specimensfrom24 cases (mean age 18/2± 4/5 years)seen at Mirza Kouchak khan and Imam Khomeini hospitals between 1992 and 1997 were assessed and the patients followed for period of five years. There were llcases (45/8%) in stage I, 2 (8.3%) in stage 11,7 (29.2%) in stage III and 4 (16.7%) in stage IV. DNA aneuploidy was revealed in 13 (54.2%) of tumors. There were 6 (15%) deaths, 7 (29.2%) recurrences and 11 (45.8%) tree trom the disease during the follow-up. DNA ploidy was significantly related to prognosis (p = 0.0006) and stage (X2= 15.9, P = 0.04). The deaths and recurrences in cases with DNA aneuploidy were 30.5% and 53.8% respectively; only 7.7% were free. The most frequent aneuploidy was in stage III and IV (85/7% and 75% respectively). Within microscopic data, mitosis, pleomorphism, necrosis and hemorrhage significantly related to DNA ploidy (p< 0.05).The trequency of aneuploidy was greater in mitosis> 8 in HPF, higher pleomorphism and presence of necrosis and hemorrage. Our study revealed that DNA aneuploidy in ovarian dysgerminoma is related to higher staging and poor prognosis.

 
Keyword(s): ANEUPLOIDY, DYSGERMINOMA, FLOWCYTOMETRY
 
 
References: 
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Cite:
APA: Copy

IZADI MOUD, N., & MOUSAVI, A., & NIASARI, M., & DADKHAH, F. (2004). EVALUATION OF THE RELATION SHIP BETWEEN OVARIAN DYSGERMINOMAS AND THE RESULTS OF DNA ANALYSIS. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 22(3), 215-219. https://www.sid.ir/en/journal/ViewPaper.aspx?id=13072



Vancouver: Copy

IZADI MOUD N., MOUSAVI A., NIASARI M., DADKHAH F.. EVALUATION OF THE RELATION SHIP BETWEEN OVARIAN DYSGERMINOMAS AND THE RESULTS OF DNA ANALYSIS. JOURNAL OF MEDICAL COUNCIL OF I.R.I.. 2004 [cited 2021April17];22(3):215-219. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=13072



IEEE: Copy

IZADI MOUD, N., MOUSAVI, A., NIASARI, M., DADKHAH, F., 2004. EVALUATION OF THE RELATION SHIP BETWEEN OVARIAN DYSGERMINOMAS AND THE RESULTS OF DNA ANALYSIS. JOURNAL OF MEDICAL COUNCIL OF I.R.I., [online] 22(3), pp.215-219. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=13072>.



 
 
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