Paper Information

Journal:   JOURNAL OF MEDICAL COUNCIL OF I.R.I.   FALL 2004 , Volume 22 , Number 3; Page(s) 215 To 219.
 
Paper: 

EVALUATION OF THE RELATION SHIP BETWEEN OVARIAN DYSGERMINOMAS AND THE RESULTS OF DNA ANALYSIS

 
 
Author(s):  IZADI MOUD N., MOUSAVI A., NIASARI M., DADKHAH F.
 
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Abstract: 

This paper studies the relationship of DNA analysis ploidy and stage of ovarian dysgerminoma and its prognosis with flowcytometric evaluation. The files and specimensfrom24 cases (mean age 18/2± 4/5 years)seen at Mirza Kouchak khan and Imam Khomeini hospitals between 1992 and 1997 were assessed and the patients followed for period of five years. There were llcases (45/8%) in stage I, 2 (8.3%) in stage 11,7 (29.2%) in stage III and 4 (16.7%) in stage IV. DNA aneuploidy was revealed in 13 (54.2%) of tumors. There were 6 (15%) deaths, 7 (29.2%) recurrences and 11 (45.8%) tree trom the disease during the follow-up. DNA ploidy was significantly related to prognosis (p = 0.0006) and stage (X2= 15.9, P = 0.04). The deaths and recurrences in cases with DNA aneuploidy were 30.5% and 53.8% respectively; only 7.7% were free. The most frequent aneuploidy was in stage III and IV (85/7% and 75% respectively). Within microscopic data, mitosis, pleomorphism, necrosis and hemorrhage significantly related to DNA ploidy (p< 0.05).The trequency of aneuploidy was greater in mitosis> 8 in HPF, higher pleomorphism and presence of necrosis and hemorrage. Our study revealed that DNA aneuploidy in ovarian dysgerminoma is related to higher staging and poor prognosis.

 
Keyword(s): ANEUPLOIDY, DYSGERMINOMA, FLOWCYTOMETRY
 
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