Paper Information

Journal:   JOURNAL OF MEDICAL COUNCIL OF I.R.I.   SUMMER 2004 , Volume 22 , Number 2; Page(s) 91 To 96.
 
Paper: 

A COMPARISONOF SERUM LIPID AND LIPOPROTEINS BEFORE AND AFTER THREE MONTHS USE OF TRIPHASIC AND MONOPHASIC CONTRACEPTIVE PILLS

 
 
Author(s):  KESHAVARZ M., RAHIMI KIAN F., FAHIMI B., MEHRAN A.
 
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Abstract: 

Combined oral contraceptive pills (OCP) exert different pharmacodynamic effects such as effect on the lipid metabolism. Because the OCP effects on serum lipid and lipoproteins depend on the amount of hormone and biologic effects of estrogen and progesterone in body, this semi experimental and prospective study was done to compare serum lipid and lipoproteins before and after three months use of triphasic and monophasic levenorterol oral contraceptive pills in seventy subjects who were referred to six community health care centers in Shahrood and made a request for oral contraceptive pills. Between two groups there were no differences in age, parity, BMI, serum Cholesterol, Trigeliceride, HDL-C and LDL-C. The results of the research showed that: Serum cholesterol, HDL-C and LDL-C did not change after three months use of the triphasic levenorgestrel pill but there were meaningful differences in mean of serum triglyceride. Serum cholesterol and LDL-C increased and HDL-C decreased after three months use of the monophasic levenorgestrel as well and there was no meaningful differences in mean of serum triglyceride.
In this study monophasaic contraceptive pill had a negative effect on HDL-C as a protective factor for heart disease which is compatible with other studies. The role of changes in serum lipids in producing coronary artery disease in women consuming OCP is not know, however a decrease ,in these changes seems logical, therefore the use of combined contraceptive pill with low levonorgestrel hormone and conducting an epidemiological survey to study the long term effects of oral contraceptive pill is suggested.

 
Keyword(s): LIPID, LIPOPROTEIN, TRIPHASIC AND MONOPHASIC ORAL CONTRACEPTIVE PILLS
 
References: 
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