| Abstract:
Background-Palmar hyperhidrosis is a fairly common disease with an unknown
etiology. Some treatment modalities have shown benefits, the most recent of which is the
injection of botulinum toxin A (BTX-A). We tried to test the beneficial effects of BTX
(Dysport) in Iranian patients.
Methods-Fifteen volunteers with severe palmar hyperhidrosis, diagnosed by iodine
starch test, were enrolled in the study. Employing a standardized scheme, Dysport was
injected intradermally into the palmar aspect of patients’ dominant hands. The distal parts of
the non-dominant hands were injected by normal saline as control. Follow-up was
performed using iodine starch test. Wilcoxon signed rank test was used for comparison
between the cases and controls.
Results-Satisfactory response to treatment was achieved in 13 out of 15 patients.
Comparing the cases with the controls, Dysport showed a significant beneficial effect
(p<0.001). Weakness of handgrip was seen in 13 patients.
Conclusion-We suggest using Dysport in the treatment of selected cases of severe
palmar hyperhidrosis.
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