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Paper Information

Journal:   JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)   Summer 2003 , Volume 7 , Number 2; Page(s) 20 To 25.
 
Paper: 

THE HEMODYNAMIC EFFECT OF CAPTOPRIL ON THE LEFT TO RIGHT SHUNT IN VSD

 
 
Author(s):  SOLGI G., JALILI Z., MASOUMI M., SABZI F., HEMATI M.
 
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Abstract: 

Background and Objective: Ventricular septal defect (VSD) is the most common pediatric congenital heart diseass (CHD). The main complications of moderate to large size VSD are recurrent respiratory tract infection, congestive heart failure, Failure to thrive, and pulmonary hypertension. These complications are the results of large left to right shut. We evaluated the effect of captopril on moderate to large size VSD.
Material and methods: Twenty patients (five girls and fifteen boys, mean age 6.5±2.8 years) were studied .Using a new echocardiographic technique we measured Qp/Qs ratio before and after treatment with Caporal (3 mg/kg/24hr for three days).
Results: After treatment with Caporal, Qp/Qs ratio decreased from 2.4±0.59 to 1.7± 0.46 after treatment. Blood pressure decreased from 104±12.mmHg to 83±9 mmHg.(p<0.001) Discussion: Captopril can decrease left to right shunt significantly in patients with moderate to large size VSD. Long term use of captopril may results in clinical improvement and delay the need for surgical correction.

 
Keyword(s): VSD, LEFT TO RIGHT SHUNT, CAPTOPRIL
 
References: 
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