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Paper Information

Journal:   JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)   Spring 2003 , Volume 7 , Number 1; Page(s) 9 To 9.
 
Paper: 

IMMUNE RESPONSE TO HEPATITIS B VACCINE IN HEALTH CARE WORKERS OF KERMANSHAH

 
 
Author(s):  JANBAKHSH A.R., HATAMI H., SAYAD B., AIENI P., HASHEMIAN A.H.
 
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Abstract: 

Background & Objectives: hepatitis B is a major health problem in Iran. Although seroconversion in vaccinated persons is estimated to be more than 90%, immune response to hepatitis B vaccine has been reported to be varied in different studies. This study was done to assess the vaccine effects in health care workers (HCWs).
Materials and Methods: I this descriptive, cross sectional study, HBSAb titer in 138 HBCAb negative, vaccinated HCWs in 10 health care centers was assessed using ELISA method. Of 138 HCWs, 60.1% were females and 39.9 males.
Results: 69.9% developed protective immune response. Age was a significant factor in responsiveness. Sex, weight, and last vaccination time had no significant role.
Discussion: In our study, rate of immune response to hepatitis B was low. Thus, revaccination may be necessary for nonresponders. We suggest that cost-effectiveness of the Heberbiovac HB vaccine should be re-evaluated in high risk groups.

 
Keyword(s): HEPATITIS B, IMMUNE RESPONSE, HEBERBIOVAC HB, HCWS, HBV
 
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