Paper Information

Journal:   JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)   Fall 2002 , Volume 6 , Number 3; Page(s) 17 To 24.
 
Paper: 

EFFICACY OF HYDROXY UREA IN THALASSEMIA INTERMEDIA

 
 
Author(s):  EHSAANI M.A., HEDAYATI ASL A.A., BAAGHERI A.R.
 
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Abstract: 

Introduction and Objectives: There is some controversy over the clinical efficacy of Hydroxy urea in Thalassemia intermedia.
Materials and Methods: Therapeutic efficacy of Hydroxy urea was evaluated in 16 patients with thalassemia intermedia, by measuring total hemoglobin and hemoglobin F levels before and 6months after treatment with Hydroxy urea (20 mg/kg/day).
Results: Mean increases in total hemoglobin and hemoglobin F levels 6mo after treatment with Hydroxy urea were 1.47±1.12 gm/dl and 1.43±1.12 gm/dl, respectively. The most common mutation was found to be IV S II-I betaglobin.
Discussion and Conclusions: Use of Hydroxy urea in thalassemia intermedia is associated with increases in total hemoglobin and hemoglobin F levels.

 
Keyword(s): THALASSEMIA INTERMEDIA, HYDROXY UREA, IV S II-I MUTATION, HEMOGLOBIN
 
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