Paper Information

Journal:   JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)   Fall 2002 , Volume 6 , Number 3; Page(s) 1 To 8.
 
Paper: 

THE EFFECTS OF REPEATED CYANIDE INJECTION ON RAT S HEART RESISTANCE AGAINST ISCHEMIA

 
 
Author(s):  SHAKIBAEI D., NALEINI M., NEJAATISAFAA A.A.
 
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Abstract: 

Introduction and Objectives: Since cyanide is a strong inhibitor of cytochrome oxidase and metabolism, we need to know whether it is useful in increasing cardiac resistance to ischemia.
Materials and Methods: Male rats received either 1.7mg/kg potassium cyanide or normal saline transperitoneally for 35 days. Then, isolated hearts were examined at baseline, during ischemia and after return to normal perfusion state.
Results: Coronary blood flow, left ventricular pressure and contractility (dp/dt) were similar in two groups, but at ischemic state (p<0.005) and at recovery to normal state (p<0.05) there were statistically significant differences in left ventricular pressure and contractility (dp/dt) between the two groups.
Discussion and Conclusions: It seams that cyanide induce cardiac resistance to ischemic effects in rats.

 
Keyword(s): CYANIDE, ISCHEMIA, ISOLATED HEART, LEFT VENTRICULAR PRESSURE, CARDIAC PROTECTION
 
References: 
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